Clinical as well as statistical knowledge is needed when determining how subfertility trials are analysed
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چکیده
منابع مشابه
Arterial stiffness as surrogate end point: needed clinical trials.
Classic risk scores may underestimate the risk of cardiovascular (CV) events in specific risk groups suitable for primary prevention, such as asymptomatic hypertensive subjects. Particularly, those considered as at intermediate risk may benefit the most from a reassessment of their CV risk using novel biomarkers. In primary prevention, some imaging biomarkers, such as arterial stiffness, enhanc...
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The objective of this short manuscript is to build on the work of Hauer (2008) and incorporate the concept associated with the power of a test (or Type II error) to calculate the necessary number of accidents in before-after studies. Statistical power plays an important role for minimizing false negatives in various types of studies. The consequences of ignoring the power in estimating the mini...
متن کاملQuestioning assent: how are children's views included as families make decisions about clinical trials?
BACKGROUND Assent is used to take children's wishes into account when they are invited into clinical trials, but the concept has attracted considerable criticism. We investigated children's accounts of decision-making with the aim of informing practice in supporting children when invited to join a clinical trial. METHODS We audio-recorded qualitative, semi-structured interviews with 22 childr...
متن کاملAdverse Event Reporting in Clinical Trials: Time to Include Duration as Well as Severity
Assessing the efficacy of therapy involves a complex interplay between the risks and benefits within particular patient populations. The concept of patient benefit has been well established. Direct patient benefits are typically assessed with regard to patients living longer, living better, or both. Assessing risks of therapy can be more difficult. To properly assess risks, one must have a clea...
متن کاملDo NIHR health technology assessment randomised clinical trials perform as well as expected?
Results 125 clinical trials published in the HTA Journal Series met the inclusion. Five trials were reported to have been abandoned and were excluded from analyses. 72% of clinical trials achieved 50% or better of their original recruitment target. 90% of clinical trials recruited their targeted number of centres with 50% recruiting more than the initial number they expected. One third of trial...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2003
ISSN: 1460-2350
DOI: 10.1093/humrep/deh019